Uvbi1^C57BL/6NCr
QTL Variant Detail

Summary

• QTL variant: Uvbi1^C57BL/6NCr
• Name: UVB induced immunosuppression 1; C57BL/6NCr
• MGI ID: MGI:2157865
• QTL: Uvbi1 Location: Chr10:103909085-103909229 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 24.71 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6NCr

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68418

Genome wide scan was performed on 100 BALB/cAnNCr x (BALB/cAnNCr x C57BL/6NCr)F1 backcross animals to map QTLs associated with UVB radiation-induced immunosuppression. Parental strains BALB/cAnNCr exhibits low susceptibility to immunosuppression whereas parental strain C57BL/6NCr exhibits high susceptibility to immunosuppression. Two significant QTLs, Uvbi1 and Uvbi2, were mapped to mouse chromosome 10 at approximately 29 cM (P<0.05 at D10Mit70) and mouse Chromosome 17 at approximately 23.2 cM (P = 0.1 at D17Mit49). Uvbi1 is associated with decreased susceptibility to UVB radiation-induced immunosuppression while Uvbi2 is associated with increased susceptibility to UVB radiation-induced immunosuppression. Uvbi1 maps near Gp49b, the gene for a membrane glycoprotein which inhibits mast cell signaling and may be a candidate gene. Uvbi2 maps distal to the MHC complex.

References

• Original: J:68418 Clemens KE, et al., Genetic control of susceptibility to UV-induced immunosuppression by interacting quantitative trait loci. Genes Immun. 2000;1(4):251-9
• All: 1 reference(s)