About   Help   FAQ
Asm1MRL/MpJ
QTL Variant Detail
Summary
QTL variant: Asm1MRL/MpJ
Name: autoimmune sialadenitis in MRL mice 1; MRL/MpJ
MGI ID: MGI:2157890
QTL: Asm1  Location: unknown  Genetic Position: Chr10, Syntenic
Variant
origin
Strain of Specimen:  MRL/MpJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers sialadenitis susceptibility compared to C3H/HeJ. (J:66459)
Inheritance:    Not Specified
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Notes
Asm1 interacts additively with Asm2 and a locus at D18Mit227.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66459

175 MRL/MpJ-Tnfrsf6lpr/Tnfrsf6lpr x (MRL/MpJ-Tnfrsf6lpr/Tnfrsf6lpr X C3H/HeJ-Tnfrsf6lpr/Tnfrsf6lpr)F1 backcross animals were typed for 139 microsatellite markers at an average spacing of 10 cM (excluding sex chromosomes) to identify QTLs associated with susceptibility to autoimmune sialadenitis.Parental strain MRL/MpJ-Tnfrsf6lpr/Tnfrsf6lpr is highly susceptible to sialadenitis (93.3% incidence) compared to parental strain C3H/HeJ-Tnfrsf6lpr/Tnfrsf6lpr (4% incidence). A highly significant locus, Asm1 (autoimmune sialadenitis in MRL mice 1), maps to mouse Chromosome 10 from 38.4 cM - 40.0 cM (LOD = 4.8 at D10Mit115 and D10Mit259). Suggestive loci mapped to mouse Chromosome 18 at 22 cM (LOD = 3.7 at D18Mit227) and mouse Chromosome 1 at 65 cM (LOD = 2.9 at D1Mit494). Asm1, D18Mit227, and D1Mit494 appear to interact in an additive fashion. Asm1 maps near another autoimmune QTL, Lmb4. A female-specific locus, Asm2, mapped to mouse Chromosome 4 from 48.5 cM - 53.6 cM (LOD = 4 at D4Mit255 and D4Mit199).

References
Original:  J:66459 Nishihara M, et al., Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice: additive and hierarchical properties of polygenic inheritance. Arthritis Rheum. 1999 Dec;42(12):2616-23
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory