Insq10^129/SvIr
QTL Variant Detail

Summary

• QTL variant: Insq10^129/SvIr
• Name: insulin QTL 10; 129/SvIr
• MGI ID: MGI:2157923
• QTL: Insq10 Location: Chr12:100532075-100532224 bp Genetic Position: Chr12, cM position of peak correlated region/allele: 50.87 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: 129S6/SvEvTac

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to hyperinsulinemia compared to C57BL/6. (J:61489)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:61489

A genome scan with an average marker resolution of 20 cM was conducted on 6 month old male mice from a (C57BL/6 x 129SvIR)F2 intercross to map QTLs affecting susceptibility to hyperinsulinemia. Female mice of either strain do not develop hyperinsulinemiaand were excluded from the study. The 129SvIR strain carries a mutation in the insulin receptor gene on Chromosome 8 and develops extreme hyperinsulinemia (elevated blood insulin). C57BL/6 does not develop hyperinsulinemia with or without mutation to theinsulin receptor gene. The authors mapped 2 major QTLs involved in modulating blood insulin levels: Insq7 on Chromosome 2 spanning 27.6 cM - 42.9 cM (LOD = 5.58 at D2Mit151) and Insq9 on Chromosome 10 spanning 29 cM - 69 cM (LOD = 5.58 at D10Mit42). Also mapped were 3 suggestive QTLs: Insq6 on Chromosome 1 spanning 38.3 cM - 59.7 cM (LOD = 3.58 at D1Mit19), Insq8 on Chromosome 6 at 56.6 cM (LOD = 2.79 at D6Mit201), and Insq10 on Chromosome 12 at 44.1c M (LOD = 3.11 at D12Mit231). Insq7 on Chromosome 2 andInsq9 on Chromosome 10 span a broad region and may contain multiple genes modulating plasma insulin levels.

References

• Original: J:61489 Kido Y, et al., Genetic modifiers of the insulin resistance phenotype in mice. Diabetes. 2000 Apr;49(4):589-96
• All: 1 reference(s)