Bgeq8^SM/J
QTL Variant Detail

Summary

• QTL variant: Bgeq8^SM/J
• Name: body growth early QTL 8; SM/J
• MGI ID: MGI:2157927
• QTL: Bgeq8 Location: unknown Genetic Position: Chr10, cM position of peak correlated region/allele: 66.75 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Candidate Genes

J:99477

Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes.

Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:32208

Quantitative trait loci (QTLs) effecting age specific body growth rates in mice were mapped using 535 F2 intercross mice from a (LG/J x SM/J)F1 cross. LG/J mice exhibit a large size at 60 days of age whereas SM/J exhibit a Small size. QTLs on 16 of 19 autosomes effective age specific growth was detected in a genome wide scan using microsatellite markers. QTL marker Bgeq8 was associated with early growth rate and mapped to mouse Chromosome 10 near D10Mit14.

J:60662

Quantitative trait loci (QTLs) effecting age specific body growth rates in mice were mapped in a previous experiment using 535 F2 intercross mice from a (LG/J x SM/J)F1 cross (See J:32208). Here an additional 510 F2 mice were analyzed. LG/J mice exhibit a large size at 60 days of age whereas SM/J exhibit a small size. QTL marker Bgeq8 was reaffirmed as mapping to mouse Chromosome 10.

References

• Original: J:60662 Vaughn TT, et al., Mapping quantitative trait loci for murine growth: a closer look at genetic architecture. Genet Res. 1999 Dec;74(3):313-22
• All: 2 reference(s)