Oriq5^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Oriq5^C57BL/6J
• Name: ovulation rate QTL 5; C57BL/6J
• MGI ID: MGI:2157951
• QTL: Oriq5 Location: unknown Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased ovulation rate compared to A/J. (J:58026)
• Inheritance: Not Specified

Notes

Animals with this allele ovulate 4.4 more eggs out of cumulus compared to animals carrying the A/J allele.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:58026

Linkage analysis was performed with 167 (C57BL/6J x A/J) x A/J backcross mice using 232 markers to identify loci affecting hormone-induced ovulation rate (HIOR) in female mice. The C57BL/6J strain releases 6-8 times more eggs (40-54 eggs in cumulus) thanA/J (8-9 eggs in cumulus) in response to exogenous gonadotropins. The higher response in C57BL/6J is associated with higher ovarian aromatase activity and estrogen production in this strain. Mapping confirmed 4 previously mapped QTLs, Oriq1, Oriq2, Oriq3,and Oriq4, on mouse chromosomes 9, 2, 6, and X, respectively. A new QTL, Oriq5 (LOD = 3.94), was identified on proximal chromosome 10 in linkage with D10Nds1, Mpmv12, and D10Mit31 spanning 6 cM - 36 cM. A possible candidate gene for Oriq5 is estrogen receptor alpha, Esr1.

References

• Original: J:58026 Spearow JL, et al., Mapping genes that control hormone-induced ovulation rate in mice. Biol Reprod. 1999 Oct;61(4):857-72
• All: 1 reference(s)