Scc6^STS/A
QTL Variant Detail

Summary

• QTL variant: Scc6^STS/A
• Name: colon tumor susceptibility 6; STS/A
• MGI ID: MGI:2157958
• QTL: Scc6 Location: Chr11:6880277-89019734 bp Genetic Position: Chr11, cM position of peak correlated region/allele: 7.3 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: STS/A

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to colon tumors compared to BALB/cHeA. (J:57235)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:57235

Susceptibility to colon cancer was analyzed in CcS (Background = BALB/cHeA Donor = STS/A )recombinant congenic strains CcS-3, CcS-5 and CcS-11. Susceptibility locus Scc6 was associated with mouse Chromosome 11 marker D11Mit2 within a range from marker D11Mit71 to marker D11Mit162.

References

• Original: J:57235 van Wezel T, et al., Four new colon cancer susceptibility loci, Scc6 to Scc9 in the mouse. Cancer Res. 1999 Sep 1;59(17):4216-8
• All: 1 reference(s)