Arrb2^tm1Rjl
Targeted Allele Detail

Summary

• Symbol: Arrb2^tm1Rjl
• Name: arrestin, beta 2; targeted mutation 1, Robert J Lefkowitz
• MGI ID: MGI:2157960
• Synonyms: Arr3^-, Arrb2^-, betaarr2^-, betarr2-KO
• Gene: Arrb2 Location: Chr11:70323461-70331654 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Arrb2^tm1Rjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59162
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: PGK-neomycin cassette replaced the entire second exon. This resulted in the deletion of amino acids 9-19. The absence of protein was demonstrated by immunoblotting of extracts from brainstem, periaqueductal gray tissue, spleen, lung, and skin. (J:59162)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Arrb2 Mutation: 27 strains or lines available

References

• Original: J:59162 Bohn LM, et al., Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science. 1999 Dec 24;286(5449):2495-8
• All: 145 reference(s)