Arrb1^tm1Jse
Targeted Allele Detail

Summary

• Symbol: Arrb1^tm1Jse
• Name: arrestin, beta 1; targeted mutation 1, J G Seidman
• MGI ID: MGI:2157962
• Synonyms: Arrb1^-
• Gene: Arrb1 Location: Chr7:99184673-99255978 bp, + strand Genetic Position: Chr7, 54.09 cM
• Alliance: Arrb1^tm1Jse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44953
• Parent Cell Line: C1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by the insertion of a neomycin resistance cassette and vector sequences through homologous recombination. The insertion results in a defined duplication of a large region of sequence within the gene. The neo cassette is located between the redundant segments, disrupting expression. Northern analysis of total heart and kidney RNA demonstrated that no detectable transcript was present in homozygous mice. Western analysis from crude cytosolic brain preparations failed to detect protein in homozygous mice. (J:44953)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arrb1 Mutation: 28 strains or lines available

References

• Original: J:44953 Conner DA, et al., beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation. Circ Res. 1997 Dec;81(6):1021-6
• All: 62 reference(s)