H2-Aa^b-tm1Blt
Targeted Allele Detail

Summary

• Symbol: H2-Aa^b-tm1Blt
• Name: histocompatibility 2, class II antigen A, alpha; targeted mutation 1, Horst Bluethmann
• MGI ID: MGI:2157977
• Synonyms: Aa⁰, Aalpha^-, H2-Aa^tm1Blt, MHC class II-
• Gene: H2-Aa Location: Chr17:34501718-34506797 bp, - strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Aa^b-tm1Blt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16372
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a PGK-neomycin resistance cassette into exon 2, which encodes the alpha-1 domain of the A-alpha chain, disrupted the gene. Cytofluorometric analyses of lymphocytes from thymus and lymph nodes did not detect expression of the A-alphaA-beta heterodimer in homozygous mutant mice. (J:16372)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H2-Aa Mutation: 30 strains or lines available

References

• Original: J:16372 Kontgen F, et al., Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int Immunol. 1993 Aug;5(8):957-64
• All: 45 reference(s)