Scpro2^DBA/2
QTL Variant Detail

Summary

• QTL variant: Scpro2^DBA/2
• Name: stem cell proliferation 2; DBA/2
• MGI ID: MGI:2157984
• QTL: Scpro2 Location: unknown Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: DBA/2

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers shorter life span and higher cell cycling compared to C57BL/6. (J:54115)
• Inheritance: Not Specified

Notes

This allele is associated with higher stem cell cycling rates and shorter life span.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:54115

26 BXD recombinant inbred (RI) strains and 12 BXH REI strains (B = C57BL/6J, D = DBA/2J, H = C3H/HeJ) were screened for loci associated with hemopoietic S-phase cell cycling using a mapping panel. C57BL/6J progenitor strain tends to have lower cell cycling times and longer life span whereas progenitor strains DBA/2J and C3H/HeJ tend to have higher cell cycling times and shorter life spans. Scpro1 (stem cell proliferation) and Scpro2, mapped to mouse chromosome 7 at 6 cM (LOD = 3.4 at D7Ncvs38) and mouse chromosome 11 at 31 cM (LOD = 3.2 at D11Ncvs76), respectively, in the BXD RI strains and were confirmed in the BXH RI strains. DBA/2J-derived alleles at Scpro1 and Scpro2 predisposed animals to 25% shorter life spans and higher cell cycling. Scpro3, a locus associated with cell cycling mapped to mouse chromosome 10 at 60 cM (LOD = 3.7 at Iapls2-37) in the BXH RI strains and is located near the Kit1 gene.

J:78926

Scpro2, a QTL associated with stem cell proliferation rates, was mapped and confirmed in 33 BXD (B=C57BL/6; D=DBA/2) recombinant inbred (RI) strains and 60 C57BL/6 x (C57BL/6 x DBA/2)F1 backcross animals. Scpro2 mapped to D11Mit131 (29 CM) in the BXD RI set and to D11Mit178 (47 cM) in the backcross set. DBA/2-derived alleles are associated with higher cell proliferation rates. Scpro2 was further confirmed in congenic line B6.D2-Scpro2. This congenic carries DBA-derived DNA from 39 cM - 49 cM on Chromosome 11 on a C57BL/6 genetic background. This congenic recapitulates the high cell cycling rates of donor strain DBA/2. Potential candidate genes for Scrpo 2 are Pafah1b1 and Tbx2.

References

• Original: J:54115 De Haan G, et al., Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span. FASEB J. 1999 Apr;13(6):707-13
• All: 2 reference(s)