Cliff^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Cliff^NZB/BlNJ
• Name: cliff drop aversion; NZB/BlNJ
• MGI ID: MGI:2157998
• QTL: Cliff Location: Chr15:3489694-3489829 bp Genetic Position: Chr15, cM position of peak correlated region/allele: 1.84 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers earlier cliff drop aversion compared to C57BL/6By. (J:53794)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53794

Nineteen measures of sensorial, motor and body weight were subject to analysis in 389 female and male mice derived from reciprocal F1 and F2 mating of strains C57BL6/By and NZB/BlNJ . These traits were mapped via QTL analysis. In total 36 traits were mapped to chromosomes of which a number reached a threshold LOD score of 3.13 and were thus concidered significant. One such QTL, Cliff aversion (Cliff) mapped with mouse Chromosome 15 marker D15Mit13 with a LOD score of 3.61. NZB/BlNJ-derived alleles confer earlier cliff drop aversion response with dominant inheritance.

References

• Original: J:53794 Le Roy I, et al., Preweanling sensorial and motor development in laboratory mice: quantitative trait loci mapping. Dev Psychobiol. 1999 Mar;34(2):139-58
• All: 1 reference(s)