Estq4^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Estq4^C57BL/6J
• Name: estradiol regulated response QTL 4; C57BL/6J
• MGI ID: MGI:2158118
• QTL: Estq4 Location: Chr10:117986516-117986649 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 66.65 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased leukocyte infiltration in the presence of C57BL/6J alleles at Estq1. (J:53494)
• Inheritance: Not Specified

Notes

Estq4 participates in interactions with Estq1 and Estq3.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52898

To understand the overall genetic control of estradiol regulated uterine response, the authors performed multiple trait analysis for both QTLs contributing to uterine weight and infiltrating eosinophils. Linkage was found to marker loci D4Mit6 (Estq1; LRT = 15.05), D5Mit296 (Estq2; LRT = 17.84), D10Mit180 (LRT = 16.02) and D11Mit67 (Estq3; LRT = 14.38; [a] = 0.10 and [a] = 0.05 thresholds equal 14.60 and 6.72, respectively). Based on the significance of D10Mit180 eosinophil infiltration, significant interaction of D10Mit180 in estradiol regulated responses, and the significance of the locus in mutilpe trait analysis, the QTL linked to D10Mit180 has been designated as Estq4.

References

• Original: J:52898 Roper RJ, et al., Interacting quantitative trait loci control phenotypic variation in murine estradiol-regulated responses. Endocrinology. 1999 Feb;140(2):556-61
• All: 2 reference(s)