Sle12^NZM2410/Aeg
QTL Variant Detail

Summary

• QTL variant: Sle12^NZM2410/Aeg
• Name: systematic lupus erythematosus susceptibility 12; NZM2410/Aeg
• MGI ID: MGI:2158123
• QTL: Sle12 Location: Chr10:122041304-122041528 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 70.36 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZM2410/Aeg

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Heterozygous animals exhibit glomerulonephritis resistance. (J:52863)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52863

156 (NZM2410/Aeg x C57BL/6)F2 animals were screened for 193 polymorphic markers to identify QTLs affecting autoimmune lupus-like phenotypes. Inbred strain NZM2410 is susceptible to autoimmune disease while inbred strain C57BL/6 is resistant.

5 previously identified loci were detected on mouse chromosomes 1, 6, 7, and 11, and 2 new loci were identified on mouse chromosomes 10 and 11. Sle1 on mouse chromosome 1, previously identified by Morel in 1994 (J:25006), was detected for linkage to splenomegaly at D1Mit36 (LOD = 8) and suggestive linkage to anti-dsDNA IgG production at D1Mit15 (LOD = 4.18) in the present cross.

A previously identified locus on mouse chromosome 6, Lbw4 (Kono, J:20991), was detected for linkage to anti-MPO production at D6Mit14 (LOD=4.61)and anti-dsDNA production at D6Mit374 (LOD = 2.93).

1.22.2016 Curator Note: Because Lbw4 was originally mapped in 1995 in J:20991 using an (NZB/BlScr x NZW/LacScr)F2 intercross, which differs from the mapping population used here, we consider the current study a separate mapping experiment and have named this QTL Sle23, systematic lupus erythematosus susceptibility 23 .

Linkage to glomerulonephritis (GN) was detected on mouse chromosome 7 at D7Mit25 (LOD = 5.48) and linkages to anti-ssDNA IgG production, anti-thryoglobulin production, and antinuclear antibody production were detected at D7Mit85 (LOD = 4.99). This interval colocalizes with Sle3 (Morel, J:25006) and Lbw5 (Kono, J:20991). Sle3 appears to have a sex-influence in the present cross: female animals show greater GN penetrance than male animals.

1.22.2016 Curator Note: Both Sle3 and Lbw5 were originally mapped in different mapping populations then used here; we consider the current study a separate mapping experiment and have named the QTL identified on Chr 7 at D7Mit25 Sle24, systematic lupus erythematosus susceptibility 24.

Linkage to anti-dsDNA production was detected on mouse chromosome 7 at D7Mit178 (LOD = 5.47). The locus was labeled Sle20 and colocalized with Lrdm1.

A locus for GNA and anti-dsDNA IgG production was detected on mouse chromosome 11 at D11Mit20 (GN LOD = 3.26, anti-dsDNA IgG LOD = 3.10) andcolocalized with Lbw8 (Kono, J:20991). A possible candidate gene for this locus is Inf4.

Novel QTLs for acute GN Sle12 and Sle13 were detected on mouse chromosome 10 at D10Mit35 (LOD = 3.54) and mouse chromosome 11 at D11Mit39 (LOD = 2.79), respectively.Apossible candidate gene for Sle12 is Ifng.

References

• Original: J:52863 Morel L, et al., Multiplex inheritance of component phenotypes in a murine model of lupus. Mamm Genome. 1999 Feb;10(2):176-81
• All: 1 reference(s)