Lrnx8^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Lrnx8^C57BL/6J
• Name: learning-contextual 8; C57BL/6J
• MGI ID: MGI:2158219
• QTL: Lrnx8 Location: unknown Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased freezing fear response compared to C57BL/6J. (J:43837)
• Inheritance: Other (see notes)

Notes

Lrnx8 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:43837

479 (C57BL/6J x DBA/2J)F2 animals were used to map QTLs involved in fear conditioned response. 84 markers at an average density of 20 cM were assayed in a selective genotyping strategy. The C57BL/6J inbred strain displays increased freezing (fear response) when introduced to an environment associated with electroshock (contextual), an auditory cue (conditioned stimulus) associated with electroshock, or an altered environment (altered context) compared to DBA/2J. In F1 animals the freezing phenotype resembles the C57BL/6J parental. Lrnx8, a QTL associated with contextual fear response, mapped to a region of chromosome 10 from 4 cM - 25 cM yielding a maximum LOD score of 4.7 at approximately 16 cM. Increased freezing is associated with C57BL/6J-derived alleles and the effect of this QTL appears additive. This locus also shows significant association to freezing to a conditioned stimulus (LOD = 4.6). No obvious candidate genes are found at this locus and no epistasis could be detected.

References

• Original: J:43837 Wehner JM, et al., Quantitative trait locus analysis of contextual fear conditioning in mice. Nat Genet. 1997 Nov;17(3):331-4
• All: 1 reference(s)