Foxj1^tm1Slb
Targeted Allele Detail

Summary

• Symbol: Foxj1^tm1Slb
• Name: forkhead box J1; targeted mutation 1, Steven L Brody
• MGI ID: MGI:2158221
• Synonyms: FoxJ1^-, Foxj1^lacZ, HFH-4 -
• Gene: Foxj1 Location: Chr11:116221530-116226225 bp, - strand Genetic Position: Chr11, 81.16 cM
• Alliance: Foxj1^tm1Slb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73616
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted using neomycin resistance gene driven by a PGK promoter and fused with a lacZ gene. Insertion of the targeting cassette occurred in the first exon. Homozygous mutant animals did not express mRNA or protein as demonstrated by Northern and Western analysis. (J:73616)

Disease models

Expression

In Mice Carrying this Mutation:	281 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxj1 Mutation: 21 strains or lines available

References

• Original: J:73616 Brody SL, et al., Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. Am J Respir Cell Mol Biol. 2000 Jul;23(1):45-51
• All: 17 reference(s)