Mop2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Mop2^C57BL/6J
• Name: morphine preference 2; C57BL/6J
• MGI ID: MGI:2158228
• QTL: Mop2 Location: Chr10:9289119-29028424 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 3.04 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased morphine preference compared to DBA/2J. (J:17972)
• Inheritance: Other (see notes)

Notes

This allele is consistent with a dominant or additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:17972

Morphine consumption was assessed in 606 F2 mice from a C57BL/6J x DBA/2J intercross. A subset of the 606 progeny were tested for QTL (quantitative trait analysis).

An increase in the preference for morphine consumption, Mop2, was mapped between flanking microsatellite markers D10Mit28 and D10Mit3 on Chromosome 10 with a lod score of 20.0.

References

• Original: J:17972 Berrettini WH, et al., Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains [see comments]. Nat Genet. 1994 May;7(1):54-8
• All: 3 reference(s)