Atp2a2^tm1Ges
Targeted Allele Detail

Summary

• Symbol: Atp2a2^tm1Ges
• Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; targeted mutation 1, Gary E Shull
• MGI ID: MGI:2158235
• Synonyms: SERCA2a^-, SERCA2a knockout
• Gene: Atp2a2 Location: Chr5:122591576-122640288 bp, - strand Genetic Position: Chr5, 62.38 cM, cytoband F
• Alliance: Atp2a2^tm1Ges page

Squamous cell carcinomas and papillomas of keratinized epithelial tissues in Atp2a2^tm1Ges/Atp2a2⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52186
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing the promoter, transcription initiation site, the first two exons and part of the third exon was replaced with a neomycin selection cassette. (J:52186)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Atp2a2^tm1Ges

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atp2a2 Mutation: 76 strains or lines available

References

• Original: J:52186 Periasamy M, et al., Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene. J Biol Chem. 1999 Jan 22;274(4):2556-62
• All: 19 reference(s)