Wg4^CAST/EiJ
QTL Variant Detail

Summary

• QTL variant: Wg4^CAST/EiJ
• Name: weight gain in high growth mice 4; CAST/EiJ
• MGI ID: MGI:2158257
• QTL: Wg4 Location: unknown Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: CAST/EiJ

Variant description

• Allele Type: QTL
• Inheritance: Other (see notes)

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 11, candidate genes for diabesity QTL Nidd4n (2 cM) are Dbn1 (34 cM- **Note: Location of Dbn1 is 34 cM on mouse Chromosome 13 according to mapping data in the MGI database**) and Dvl2 (36.5 cM). Both Dbn1 and Dvl2 show differential expression on the restricted and unrestricted diets on the A/A^vy background.

Candidate genes for diabesity QTLs Nidd1n (31 cM), Bwtq5 (27.8 cM), Wt10q3 (32 cM), Wt6q3 (36 cM) are Nola2 (28.5 cM, formerly Nhp2), Sept8 (28.75 cM), Skp1a (31 cM), and Mpdu1 (39 cM). Skp1a and Nola2 both show differential expression between restricted and unrestricted diets on the A/A^vy background. Sept8 shows differential expression between A/a and A/A^vy animals on the restricted diet.

Candidate genes for diabesity QTLs Wg4 (46 cM) and Bw4 (55 cM) are Dusp14 (48 cM), Spag7 (42 cM), Derl2 (42 cM, formerly Flana), Sfrs1 (49 cM), and Rara (57.8 cM). Dusp14, Derl2, and Spag7 all show differential expression between A/a and A/A^vy animals on the restricted diet. Sfrs1 shows differential expression between the restricted and unrestricted diets on the A/a background. Rara shows differential expression between the restricted and unrestricted diet on the A/a background as well as between A/a and A/A^vy animals on the restricted diet.

Fasn (72 cM) and Grb2 (75 cM) are candidate genes for diabesity QTL Nidd4 (68 cM). Fasn shows differential expression between restricted and unrestricted diets on the A/A^vy background while Grb2 shows differential expression between A/a and A/A^vy animals on the unrestricted diet.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68441

Authors indicated that enhanced growth rate in C57BL/6J-Cish2^hg/Cish2^hg mice may be modulated by other genes associated with growth. 1132 F2 mice from a cross between (C57BL/6J-Cish2^hg/Cish2^hg X CAST/EiJ)F1's yielded 274 +/+ , 596 hg/+ and 262 hg/hg mice with the hg/hg used in a genome wide scan to find QTLs associated with growth rates. A total of 15 QTLs were mapped. QTLs for total weight gain (wg1 - wg4) mapped to mouse Chromosomes 2, 8, and 11, with wg1 and wg2 mapping to mouse chromosome 2.QTLS for total carcass protein (Carp1-Carp3) mapped to Chromosomes 2, 11 and 17. QTLs for total carcass ash weight (Cara1-Cara3) mapped to mouse Chromosomes 2, 11 and 17. QTLs for percent carcass fat (Carf1 and Carf2) mapped to mouse Chromosomes 5 and 9 and QTLS for femur length (Feml1-Feml3) mapped to mouse chromosomes 2, 9, and 17.

References

• Original: J:68441 Corva PM, et al., Quantitative trait loci affecting growth in high growth (hg) mice. Mamm Genome. 2001 Apr;12(4):284-90
• All: 1 reference(s)