Atp4b^tm1Ird
Targeted Allele Detail

Summary

• Symbol: Atp4b^tm1Ird
• Name: ATPase, H+/K+ exchanging, beta polypeptide; targeted mutation 1, Ian R van Driel
• MGI ID: MGI:2158258
• Synonyms: Atp4b^kls, Atp4b^o, H/Kbeta, HKbeta^-
• Gene: Atp4b Location: Chr8:13436209-13446778 bp, - strand Genetic Position: Chr8, 5.89 cM
• Alliance: Atp4b^tm1Ird page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74022
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection casssette replaced 35 bp of exon 1. RT-PCR analysis demonstrated that no stable transcript was present in gastric tissue of homozygous mice, and western blot analysis showed that no stable protein was produced from this allele in gastric membranes derived from homozygous mice. (J:74022)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Atp4b Mutation: 31 strains or lines available

References

• Original: J:74022 Scarff KL, et al., Gastric H(+),K(+)-adenosine triphosphatase beta subunit is required for normal function, development, and membrane structure of mouse parietal cells. Gastroenterology. 1999 Sep;117(3):605-18
• All: 19 reference(s)