Bcl10^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Bcl10^tm1Mak
• Name: B cell leukemia/lymphoma 10; targeted mutation 1, Tak W Mak
• MGI ID: MGI:2158304
• Synonyms: Bcl10^-
• Gene: Bcl10 Location: Chr3:145630017-145640121 bp, + strand Genetic Position: Chr3, 71.03 cM, cytoband H3
• Alliance: Bcl10^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67297
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 2 and all of the coding sequence of exon 3 was replaced with a neomycin selection cassette inserted in reverse trancriptional orientation to the gene. Western blot analysis on embryonic fibroblast lysates derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:67297)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl10 Mutation: 16 strains or lines available

References

• Original: J:67297 Ruland J, et al., Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell. 2001 Jan 12;104(1):33-42
• All: 23 reference(s)