Bcl2^tm1Tsu
Targeted Allele Detail

Summary

• Symbol: Bcl2^tm1Tsu
• Name: B cell leukemia/lymphoma 2; targeted mutation 1, Yoshihide Tsujimoto
• MGI ID: MGI:2158305
• Synonyms: bcl-2 -
• Gene: Bcl2 Location: Chr1:106465908-106642004 bp, - strand Genetic Position: Chr1, 49.76 cM
• Alliance: Bcl2^tm1Tsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22391
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced most of the coding sequences of exon 2. Western blot analysis of spleen and thymus lysates derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:22391)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl2 Mutation: 41 strains or lines available

References

• Original: J:22391 Kamada S, et al., bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res. 1995 Jan 15;55(2):354-9
• All: 6 reference(s)