Bax^tm1Dlo
Targeted Allele Detail

Summary

• Symbol: Bax^tm1Dlo
• Name: BCL2-associated X protein; targeted mutation 1, Dennis Y Loh
• MGI ID: MGI:2158306
• Synonyms: bax-
• Gene: Bax Location: Chr7:45111121-45116322 bp, - strand Genetic Position: Chr7, 29.32 cM, cytoband B5
• Alliance: Bax^tm1Dlo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39573
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A 5.6 kb genomic fragment containing exons 2-6 was replaced with a neomycin selection cassette. (J:39573)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bax Mutation: 24 strains or lines available

Notes

This allele is described in the materials and methods of the above listed reference as a gift from D. Y. Loh, but it was not independently published.

References

• Original: J:39573 Shindler KS, et al., Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J Neurosci. 1997 May 1;17(9):3112-9
• All: 8 reference(s)