Atox1^{Gt(IRESBetageo)3Pgr}
Gene trapped Allele Detail

Summary

• Symbol: Atox1^{Gt(IRESBetageo)3Pgr}
• Name: antioxidant 1 copper chaperone; gene trap 3, Peter Gruss
• MGI ID: MGI:2158341
• Synonyms: Atox1^-
• Gene: Atox1 Location: Chr11:55337463-55352034 bp, - strand Genetic Position: Chr11, 33.07 cM
• Alliance: Atox1^{Gt(IRESBetageo)3Pgr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74249
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene was disrupted by the insertion of the gene trap vector IRES Beta-geo into intron 1. Northern blot analysis on RNA derived from E12.5 embryonic fibroblasts from homozygous mice demonstrated that no detectable transcript was produced from this allele, and western blot analysis on protein derived from E12.5 embryonic fibroblasts revealed that no detectable wild-type protein was made. (J:74249)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atox1 Mutation: 14 strains or lines available

References

• Original: J:74249 Hamza I, et al., The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6848-52
• All: 6 reference(s)