Xiap^tm1Thsn
Targeted Allele Detail

Summary

• Symbol: Xiap^tm1Thsn
• Name: X-linked inhibitor of apoptosis; targeted mutation 1, Craig B Thompson
• MGI ID: MGI:2158344
• Synonyms: Xiap^-, XIAP deficient
• Gene: Xiap Location: ChrX:41148556-41198533 bp, + strand Genetic Position: ChrX, 23.19 cM, cytoband A3-A5
• Alliance: Xiap^tm1Thsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74251
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 1 was replaced with a neomycin selection cassette inserted in reverse transcriptional orientation to the gene. Northern blot analysis demonstrated that that no detectable transcript was present in kidney or liver tissue of homozygous mice, and western blot analysis confirmed that no detectable protein was present in embryonic fibroblasts derived from homozygous mice. (J:74251)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xiap Mutation: 37 strains or lines available

References

• Original: J:74251 Harlin H, et al., Characterization of XIAP-deficient mice. Mol Cell Biol. 2001 May;21(10):3604-8
• All: 28 reference(s)