Figla^tm1Dean
Targeted Allele Detail

Summary

• Symbol: Figla^tm1Dean
• Name: folliculogenesis specific basic helix-loop-helix; targeted mutation 1, Jurrien Dean
• MGI ID: MGI:2158347
• Synonyms: Figalpha^tm, Figalpha^tm1Nih, Figalpha^tm2Nih
• Gene: Figla Location: Chr6:85993476-85997978 bp, + strand Genetic Position: Chr6, 37.55 cM
• Alliance: Figla^tm1Dean page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64677
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.8 kb genomic fragment containing the transcription and translation start sites was replaced with a neomycin selection cassette. RNAse protection assays on RNA derived from ovaries of female homozygous mice demonstrated that no detectable transcript was present. (J:64677)

Expression

In Mice Carrying this Mutation:	124 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Figla Mutation: 16 strains or lines available

References

• Original: J:64677 Soyal SM, et al., FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation. Development. 2000 Nov;127(21):4645-54
• All: 6 reference(s)