Gulo^tm1Mae
Targeted Allele Detail

Summary

• Symbol: Gulo^tm1Mae
• Name: gulonolactone (L-) oxidase; targeted mutation 1, Nobuyo Maeda
• MGI ID: MGI:2158350
• Synonyms: gulo-, Gulo^tm1Unc
• Gene: Gulo Location: Chr14:66224235-66246656 bp, - strand Genetic Position: Chr14, 34.36 cM
• Alliance: Gulo^tm1Mae page

Abnormalities in the aorta of Gulo^tm1Mae/Gulo^tm1Mae mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 3 and 4 was replaced with a neomycin selection cassette. Northern blot analysis confirmed that no detectable transcript is produced from this allele in liver of homozygous mice. (J:59931)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gulo Mutation: 28 strains or lines available

References

• Original: J:59931 Maeda N, et al., Aortic wall damage in mice unable to synthesize ascorbic acid. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):841-6
• All: 45 reference(s)