Kifc3^tm1Gsn
Targeted Allele Detail

Summary

• Symbol: Kifc3^tm1Gsn
• Name: kinesin family member C3; targeted mutation 1, Lawrence SB Goldstein
• MGI ID: MGI:2158352
• Gene: Kifc3 Location: Chr8:95826456-95929440 bp, - strand Genetic Position: Chr8, 47.12 cM
• Alliance: Kifc3^tm1Gsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67352
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 6.5 kb genomic fragment containing sequences encoding amino acids 197-507 was replaced with a splice-acceptor IRES lacZ and neomycin resistance gene fusion cassette. Northern blot analysis on RNA derived from kidney and testis tissue of homozygous mice demonstrated that no detectable transcripts were produced from this allele. (J:67352)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Kifc3^tm1Gsn/Kifc3^tm1Gsn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Phenotypes:

Affected Systems	hm1
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hematopoietic system	N
hematopoietic system phenotype	N
renal/urinary system	N
renal/urinary system phenotype	N
vision/eye	N
vision/eye phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kifc3 Mutation: 68 strains or lines available

References

• Original: J:67352 Yang Z, et al., Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3. Mol Cell Biol. 2001 Feb;21(3):765-70
• All: 1 reference(s)