Npr3^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Npr3^tm1Unc
• Name: natriuretic peptide receptor 3; targeted mutation 1, University of North Carolina
• MGI ID: MGI:2158355
• Synonyms: Npr3^tm1Smi
• Gene: Npr3 Location: Chr15:11839982-11907287 bp, - strand Genetic Position: Chr15, 5.83 cM
• Alliance: Npr3^tm1Unc page

Skeletal phenotypes of Npr3^tm1Unc/Npr3^tm1Unc mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56058
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing sequences encoding 215 amino acids of the ligand binding domain was replaced with a neomycin selection gene. Photoaffinity labeling analysis revealed that no functional protein was made in lung plasma membranes in homozygous mice. (J:56058)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npr3 Mutation: 50 strains or lines available

References

• Original: J:56058 Matsukawa N, et al., The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7403-8
• All: 11 reference(s)