Pkib^tm1Idz
Targeted Allele Detail

Summary

• Symbol: Pkib^tm1Idz
• Name: protein kinase inhibitor beta, cAMP dependent, testis specific; targeted mutation 1, Rejean L Idzerda
• MGI ID: MGI:2158356
• Gene: Pkib Location: Chr10:57508077-57617208 bp, + strand Genetic Position: Chr10, 29.22 cM
• Alliance: Pkib^tm1Idz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69600
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 3 was replaced with a neomycin selection cassette. This exon encodes both the inhibitory and nuclear export domains. Northern blot analysis demonstrated that no detectable transcript was produced from this allele in RNA derived from testis of homozygous mice. (J:69600)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pkib Mutation: 10 strains or lines available

References

• Original: J:69600 Belyamani M, et al., Reproductive function in protein kinase inhibitor-deficient mice. Mol Cell Biol. 2001 Jun;21(12):3959-63
• All: 2 reference(s)