Traf4^tm2Lind
Targeted Allele Detail

Summary

• Symbol: Traf4^tm2Lind
• Name: TNF receptor associated factor 4; targeted mutation 2, Tullia Lindsten
• MGI ID: MGI:2158362
• Gene: Traf4 Location: Chr11:78049325-78056415 bp, - strand Genetic Position: Chr11, 46.74 cM, cytoband B5-C
• Alliance: Traf4^tm2Lind page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74252
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing the entire coding region of the gene was replaced with a neomycin selection cassette inserted in reverse transcriptional orientation to the gene. Northern blot analysis on tissues derived from homozygous mice confirmed that to detectable transcript was produced from this allele. Western blot analysis on protein extracts from various tissues of homozygous mice demonstrated that no detectable protein was made from this allele. (J:74252)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf4 Mutation: 37 strains or lines available

References

• Original: J:74252 Shiels H, et al., TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs. Am J Pathol. 2000 Aug;157(2):679-88
• All: 1 reference(s)