Zmpste24^tm1Sgy
Targeted Allele Detail

Summary

• Symbol: Zmpste24^tm1Sgy
• Name: zinc metallopeptidase, STE24; targeted mutation 1, Steven G Young
• MGI ID: MGI:2158363
• Synonyms: Zmeste24-
• Gene: Zmpste24 Location: Chr4:120916434-120955438 bp, - strand Genetic Position: Chr4, 56.8 cM
• Alliance: Zmpste24^tm1Sgy page

CT scans illustrating bony lesions in Zmpste24^tm1Sgy/Zmpste24^tm1Sgy mice.

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70661
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 8 was replaced with a floxed neomycin selection cassette. Enzymatic activity assays on liver cell membranes derived from homozygous mice demonstrated reduced or absent processing of synthetic substrates, suggesting that no functional protein is produced from this allele. (J:70661)

Disease models

Expression

In Structures Affected by this Mutation:

26 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Zmpste24 Mutation: 32 strains or lines available

References

• Original: J:70661 Leung GK, et al., Biochemical studies of Zmpste24-deficient mice. J Biol Chem. 2001 Aug 3;276(31):29051-8
• All: 26 reference(s)