Npr1^tm1Mae
Targeted Allele Detail

Summary

• Symbol: Npr1^tm1Mae
• Name: natriuretic peptide receptor 1; targeted mutation 1, Nobuyo Maeda
• MGI ID: MGI:2158387
• Synonyms: Npr1^-
• Gene: Npr1 Location: Chr3:90357898-90373173 bp, - strand Genetic Position: Chr3, 39.23 cM
• Alliance: Npr1^tm1Mae page

Cardiac hypertrophy in Npr1^tm1Mae/Npr1^tm1Mae male mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74420
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 1 and part of intron 1 was replaced with a neomycin selection cassette. The deleted sequences encode 237 amino acids from the N-terminal region of the corresponding protein. Western blot analysis on kidney membranes derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:74420)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npr1 Mutation: 60 strains or lines available

References

• Original: J:74420 Oliver PM, et al., Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14730-5
• All: 29 reference(s)