Bmpr1a^tm2.1Bhr
Targeted Allele Detail

Summary

• Symbol: Bmpr1a^tm2.1Bhr
• Name: bone morphogenetic protein receptor, type 1A; targeted mutation 2.1, Richard R Behringer
• MGI ID: MGI:2158390
• Synonyms: ALK3^F, Alk3^flox, Bmpr1a^f, Bmpr1a fl, Bmpr1a^fl, Bmpr1a fx, Bmpr1a^fx, Bmpr1a^fx(exon2), Bmpr1a^tm1.1Cren, BmpRIA^flox, floxP
• Gene: Bmpr1a Location: Chr14:34133018-34225335 bp, - strand Genetic Position: Chr14, 20.81 cM
• Alliance: Bmpr1a^tm2.1Bhr page

Joint defects in Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.2Bhr Tg(Gdf5-cre,-ALPP)1Kng/0 mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75074
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination introduced a floxed neomycin resistance cassette into intron 2, and a single loxP site into intron 1. Cre-mediated recombination in vivo under the control of a CMV promoter excised the neo cassette in the germline, leaving single loxP sites flanking exon 2, which encodes roughly a third of the extracellular domain of the receptor within the ligand-binding domain. (J:75074, J:97780)

Disease models

Expression

In Mice Carrying this Mutation:	107 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	33 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmpr1a Mutation: 90 strains or lines available

References

• Original: J:75074 Mishina Y, et al., Generation of Bmpr/Alk3 conditional knockout mice. Genesis. 2002 Feb;32(2):69-72
• All: 182 reference(s)