H2-Ab1^b-tm1Gru
Targeted Allele Detail

Summary

• Symbol: H2-Ab1^b-tm1Gru
• Name: histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Michael J Grusby
• MGI ID: MGI:2158420
• Synonyms: Ab1^tm1Gru, Abb-, A^bbeta^-, Abb^tm1, Abeta-, Abeta^b-, C2-, H2-Ab1^-, H2-Ab1^tm1Glm, H2-Ab1^tm1Gru, I-A^b-, IAb^-, IAbeta-, I-Abeta^b-, [KO]Ab^b, MHC class II-, MHC-II-deficient, mII^-
• Gene: H2-Ab1 Location: Chr17:34482201-34488392 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Ab1^b-tm1Gru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74418
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 2. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins. (J:74418)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 11 strains available Cell Lines: 0 lines available
• Carrying any H2-Ab1 Mutation: 83 strains or lines available

References

• Original: J:74418 Grusby MJ, et al., Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science. 1991 Sep 20;253(5026):1417-20
• All: 323 reference(s)