Bcl2a1a^tm1Sen
Targeted Allele Detail

Summary

• Symbol: Bcl2a1a^tm1Sen
• Name: B cell leukemia/lymphoma 2 related protein A1a; targeted mutation 1, Fujiro Sendo
• MGI ID: MGI:2158426
• Synonyms: A1-a -
• Gene: Bcl2a1a Location: Chr9:88838973-88844469 bp, + strand Genetic Position: Chr9, 47.24 cM
• Alliance: Bcl2a1a^tm1Sen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52127
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.0 kb genomic fragment containing exon 1 was replaced with a neomycin selection cassette. These sequences encode the first 140 amino acids of the corresponding protein. RT-PCR analysis demonstrated that no detectable transcript was produced from this allele in neutrophils derived from homozygous mice (data not shown). (J:52127)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2a1a Mutation: 14 strains or lines available

References

• Original: J:52127 Hamasaki A, et al., Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene. J Exp Med. 1998 Dec 7;188(11):1985-92
• All: 2 reference(s)