Bcl2l2^tm1Sco
Targeted Allele Detail

Summary

• Symbol: Bcl2l2^tm1Sco
• Name: BCL2-like 2; targeted mutation 1, Suzanne Cory
• MGI ID: MGI:2158430
• Synonyms: bcl-w-, bcl-w^delta
• Gene: Bcl2l2 Location: Chr14:55120900-55125691 bp, + strand Genetic Position: Chr14, 27.98 cM
• Alliance: Bcl2l2^tm1Sco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50338
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing two-thirds of the coding region was replaced with a neomycin selection cassette flanked by loxP sites. The neomycin cassette was removed via Cre mediated recombination in the final allele. Northern blot analysis on testis RNA derived from homozygous mice demonstrated that no detectable transcript is produced from this allele, and western blot analysis confirmed that no detectable protein was present in brain, testis or pancreas of homozygous mice. (J:50338)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l2 Mutation: 19 strains or lines available

References

• Original: J:50338 Print CG, et al., Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12424-31
• All: 5 reference(s)