Bcl6^tm1Htno
Targeted Allele Detail

Summary

• Symbol: Bcl6^tm1Htno
• Name: B cell leukemia/lymphoma 6; targeted mutation 1, Masahiko Hatano
• MGI ID: MGI:2158436
• Synonyms: Bcl6^-, Bcl6^tm1Tto
• Gene: Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
• Alliance: Bcl6^tm1Htno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55952
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.0 kb genomic fragment spanning exons 3 - 6 was replaced with a neomycin selection cassette inserted in reverse transcriptional orientation to the gene. Northern blot analysis of mRNA derived from kidneys of homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:55952)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl6 Mutation: 57 strains or lines available

References

• Original: J:55952 Yoshida T, et al., The role of Bcl6 in mature cardiac myocytes. Cardiovasc Res. 1999 Jun;42(3):670-9
• All: 22 reference(s)