Bcl6^tm2Rdf
Targeted Allele Detail

Summary

• Symbol: Bcl6^tm2Rdf
• Name: B cell leukemia/lymphoma 6; targeted mutation 2, Riccardo Dalla-Favera
• MGI ID: MGI:2158438
• Synonyms: BCL-6^-
• Gene: Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
• Alliance: Bcl6^tm2Rdf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40769
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 4 through part of exon 10 was replaced with a neomycin selection cassette. Nearly all of the coding sequences were deleted in this allele. (J:40769)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bcl6^tm2Rdf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl6 Mutation: 57 strains or lines available

References

• Original: J:40769 Ye BH, et al., The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet. 1997 Jun;16(2):161-70
• All: 16 reference(s)