Bcl6^tm1Sdt
Targeted Allele Detail

Summary

• Symbol: Bcl6^tm1Sdt
• Name: B cell leukemia/lymphoma 6; targeted mutation 1, Louis M Staudt
• MGI ID: MGI:2158439
• Synonyms: BCL-6-
• Gene: Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
• Alliance: Bcl6^tm1Sdt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39815
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing coding sequences for the zinc finger DNA binding domain was replaced with a neomycin selection cassette. Western blot analysis on spleen cells derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:39815)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl6 Mutation: 57 strains or lines available

References

• Original: J:39815 Dent AL, et al., Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science. 1997 Apr 25;276(5312):589-92
• All: 26 reference(s)