Pxn^tm1Smth
Targeted Allele Detail

Summary

• Symbol: Pxn^tm1Smth
• Name: paxillin; targeted mutation 1, Sheila M Thomas
• MGI ID: MGI:2158458
• Synonyms: paxillin^-
• Gene: Pxn Location: Chr5:115644735-115694046 bp, + strand Genetic Position: Chr5, 56.1 cM
• Alliance: Pxn^tm1Smth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73970
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The allele replaces 1.6 kb of the endogenous gene with the SA-beta-geo construct. Exons 2 and 3, corresponding to amino acids 5-74, are deleted from the locus. Immunoblot analysis did not detect protein in lysates prepared from homozygous mutant embryos. (J:73970)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pxn Mutation: 60 strains or lines available

References

• Original: J:73970 Hagel M, et al., The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol. 2002 Feb;22(3):901-15
• All: 2 reference(s)