Bmp7^{Tg(BCL2)114Cro}
Transgenic Allele Detail

Summary

• Symbol: Bmp7^{Tg(BCL2)114Cro}
• Name: bone morphogenetic protein 7; transgene insertion 114, Carlo M Croce
• MGI ID: MGI:2158467
• Synonyms: Bmp7-
• Gene: Bmp7 Location: Chr2:172709805-172782114 bp, - strand Genetic Position: Chr2, 95.54 cM
• Alliance: Bmp7^{Tg(BCL2)114Cro} page

Transgene origin

• Strain of Origin: (C3H/HeJ x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Bmp7^{Tg(BCL2)114Cro} expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Bmp7^{Tg(BCL2)114Cro} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Mutation details: A transgene expressing human BCL2 under the control of the human BCL2 promoter and immunoglobulin heavy chain enhancer randomly inserted into the mouse Bmp7 gene. PCR and Southern blot analysis demonstrated that the insertion resulted in a disruption or deletion of exon 3. RT-PCR analysis demonstrated that no transcript containing sequnces from exons 4-7 could be detected, suggesting that no functional protein can be produced from this allele. (J:38288)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp7 Mutation: 37 strains or lines available

References

• Original: J:38288 Jena N, et al., BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye. Exp Cell Res. 1997 Jan 10;230(1):28-37
• All: 1 reference(s)