Bmp4^tm2Blh
Targeted Allele Detail

Summary

• Symbol: Bmp4^tm2Blh
• Name: bone morphogenetic protein 4; targeted mutation 2, Brigid L Hogan
• MGI ID: MGI:2158495
• Synonyms: Bmp4-lacZ, Bmp4^lacZ, BMP4^LacZ, Bmp4^lacZneo
• Gene: Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
• Alliance: Bmp4^tm2Blh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53311
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A DNA fragment containing most of exon 3 and including the translation initiation codon was replaced with a lacZ gene followed by a neomycin selection cassette. A beta-galactosidase protein is expressed from this allele under the control of the endogenous promoter. (J:53311)

Disease models

Expression

In Mice Carrying this Mutation:	153 assay results
In Structures Affected by this Mutation:	23 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmp4 Mutation: 23 strains or lines available

References

• Original: J:53311 Lawson KA, et al., Bmp4 is required for the generation of primordial germ cells in the mouse embryo [see comments]. Genes Dev. 1999 Feb 15;13(4):424-36
• All: 54 reference(s)