Flt3l^tm1Imx
Targeted Allele Detail

Summary

• Symbol: Flt3l^tm1Imx
• Name: FMS-like tyrosine kinase 3 ligand; targeted mutation 1, Immunex Corporation
• MGI ID: MGI:2158499
• Synonyms: FL^-, Flt3-L^-, FLT3L-
• Gene: Flt3l Location: Chr7:44780607-44785914 bp, - strand Genetic Position: Chr7, 29.14 cM, cytoband B2-C
• Alliance: Flt3l^tm1Imx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62536
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing the initiation codon and most of the sequences encoding the extracellular domain. RT-PCR analysis on RNA derived from spleen and bone marrow of homozygous mice confirmed that no detectable transcript is produced from this allele. (J:62536)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Flt3l Mutation: 14 strains or lines available

Notes

The ES cell line was described as C57BL/6 derived.

References

• Original: J:62536 McKenna HJ, et al., Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood. 2000 Jun 1;95(11):3489-97
• All: 94 reference(s)