Bmpr2^tm1Kmi
Targeted Allele Detail

Summary

• Symbol: Bmpr2^tm1Kmi
• Name: bone morphogenetic protein receptor type 2; targeted mutation 1, Kohei Miyazono
• MGI ID: MGI:2158503
• Gene: Bmpr2 Location: Chr1:59802721-59917240 bp, + strand Genetic Position: Chr1, 30.44 cM, cytoband C2
• Alliance: Bmpr2^tm1Kmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61931
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 4 and 5. These sequences encode the transmembrane domain and the amino terminal region of the kinase domain. (J:61931)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmpr2 Mutation: 46 strains or lines available

References

• Original: J:61931 Beppu H, et al., BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol. 2000 May 1;221(1):249-58
• All: 15 reference(s)