Npr1^tm1(Npr1)Unc
Targeted Allele Detail

Summary

• Symbol: Npr1^tm1(Npr1)Unc
• Name: natriuretic peptide receptor 1; targeted mutation 1, University of North Carolina
• MGI ID: MGI:2158630
• Synonyms: Npr1^tm1(Npr1)Smi
• Gene: Npr1 Location: Chr3:90357898-90373173 bp, - strand Genetic Position: Chr3, 39.23 cM
• Alliance: Npr1^tm1(Npr1)Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46175
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Npr1^tm1(Npr1)Unc expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Npr1 (MGI:97371)

• Mutation details: A gap-repair vector was used to induce a tandem duplication of the gene. Guanylate cyclase activity assays demonstrated a correlation of increased activity to gene dosage in heterozygous and homozygous mice. (J:46175)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npr1 Mutation: 60 strains or lines available

References

• Original: J:46175 Oliver PM, et al., Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2547-51
• All: 6 reference(s)