Pkia^tm1Idz
Targeted Allele Detail

Summary

• Symbol: Pkia^tm1Idz
• Name: protein kinase inhibitor, alpha; targeted mutation 1, Rejean L Idzerda
• MGI ID: MGI:2158639
• Synonyms: PKIalpha -
• Gene: Pkia Location: Chr3:7431729-7510426 bp, + strand Genetic Position: Chr3, 1.96 cM
• Alliance: Pkia^tm1Idz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61791
• Parent Cell Line: REK3 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 1 was replaced with a neomycin selection cassette. This exon encodes most of the protein. Northern blot analysis confirmed that no detectable transcript is produced from this allele. (J:61791)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pkia Mutation: 6 strains or lines available

References

• Original: J:61791 Gangolli EA, et al., Deficient gene expression in protein kinase inhibitor alpha Null mutant mice. Mol Cell Biol. 2000 May;20(10):3442-8
• All: 2 reference(s)