Prkar2b^tm1Gsm
Targeted Allele Detail

Summary

• Symbol: Prkar2b^tm1Gsm
• Name: protein kinase, cAMP dependent regulatory, type II beta; targeted mutation 1, G Stanley McKnight
• MGI ID: MGI:2158642
• Synonyms: RIIbeta -
• Gene: Prkar2b Location: Chr12:32008475-32111295 bp, - strand Genetic Position: Chr12, 13.74 cM, cytoband B1
• Alliance: Prkar2b^tm1Gsm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47453
• Parent Cell Line: REK2 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2 kb genomic fragment containing exon 1 was replaced with a neomycin selection cassette inserted in reverse transcriptional orientation to the gene. Northern blot analysis on total brain RNA derived from homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:74419)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkar2b Mutation: 27 strains or lines available

References

• Original: J:47453 Brandon EP, et al., Defective motor behavior and neural gene expression in RIIbeta-protein kinase A mutant mice. J Neurosci. 1998 May 15;18(10):3639-49
• All: 19 reference(s)