Blm^tm2Brd
Targeted Allele Detail

Summary

• Symbol: Blm^tm2Brd
• Name: Bloom syndrome, RecQ like helicase; targeted mutation 2, Allan Bradley
• MGI ID: MGI:2158669
• Synonyms: Blm^m2
• Gene: Blm Location: Chr7:80104839-80184896 bp, - strand Genetic Position: Chr7, 45.65 cM
• Alliance: Blm^tm2Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66261
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Three copies of a targeting vector inserted into the gene. The authors predict that an aberrant transcript containing 4 copies of exon 3 is made. However, western blot analysis on protein extracts of testes demonstrated that no detectable protein was produced from this allele. (J:66261)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Blm Mutation: 88 strains or lines available

Notes

Other alleles of this gene serve as models for Bloom Syndrome. This allele results in embryonic lethality and could not be studied in this context.

References

• Original: J:66261 Luo G, et al., Cancer predisposition caused by elevated mitotic recombination in bloom mice. Nat Genet. 2000 Dec;26(4):424-9
• All: 3 reference(s)