Blm^tm3Brd
Targeted Allele Detail

Summary

• Symbol: Blm^tm3Brd
• Name: Bloom syndrome, RecQ like helicase; targeted mutation 3, Allan Bradley
• MGI ID: MGI:2158670
• Synonyms: Blm-, Blm^m3
• Gene: Blm Location: Chr7:80104839-80184896 bp, - strand Genetic Position: Chr7, 45.65 cM
• Alliance: Blm^tm3Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66261
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: This allele is a derivative of Blm^tm2Brd. Three copies of a targeting vector that contained loxP sites inserted into the gene. Cre mediated recombination led to a deletion of the copies. This allele retains an extra copy of exon 3. However, western blot analysis on protein extracts of testes demonstrated that no detectable protein was produced from this allele. (J:66261)

Disease models

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Blm^tm3Brd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Blm Mutation: 88 strains or lines available

References

• Original: J:66261 Luo G, et al., Cancer predisposition caused by elevated mitotic recombination in bloom mice. Nat Genet. 2000 Dec;26(4):424-9
• All: 19 reference(s)