Bid^tm1Sjk
Targeted Allele Detail

Summary

• Symbol: Bid^tm1Sjk
• Name: BH3 interacting domain death agonist; targeted mutation 1, Stanley J Korsmeyer
• MGI ID: MGI:2158671
• Synonyms: Bid-
• Gene: Bid Location: Chr6:120870080-120894074 bp, - strand Genetic Position: Chr6, 57.02 cM
• Alliance: Bid^tm1Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57073
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.2 kb genomic fragment containing exons 1, 2 and part of 3 was replaced with a neomycin selection cassette inserted in reverse transcriptional orientation to the gene. The deleted sequences encode the BH3 domain of the protein. Western blot analysis on spleen and thymus samples derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:57073)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bid Mutation: 44 strains or lines available

References

• Original: J:57073 Yin XM, et al., Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature. 1999 Aug 26;400(6747):886-91
• All: 75 reference(s)